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KMID : 0385919940050020275
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Journal of the Korean Society of Emergency Medicine
1994 Volume.5 No. 2 p.275 ~ p.280
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A Case of Valproic Acid intoxication Due to Orfil Overdose
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Abstract
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Orfil intoxication is not encountered. But using the new knowledge about its pharmacodynamics and pharmacokinetics we could improve on its fatalities which are usally associated its central nervous system depression mediated by γ-aminobutyric
acid,
idiopathic hepatotoxicity and hemorrhagic pancreatitis thought to be mediated by immune mechanism. We report a case of valproate intoxication patient with serum valproic acid level 2020㎍/mL who died from complications of progressive liver and
pancreas
failure known to be associated with valpoic acid.
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KEYWORD
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